Effect of chloroquine in vitro: Decrease in pressure in left atria, prolongation of the effective refractory period of the atria, of the ventricular tissue and of the right papillary muscles, and dose-dependent alteration of hemodynamic and electrocardiographic parameters (with alteration of atrioventricular conduction).
In vivo studies:
In vitro and in vivo in mice, rats, and rabbits
In vitro experiments: on rat heart tissue, incubated with chloroquine +/- diazepam.
In vivo experiments: Toxicity models in rats and rabbits anesthetized with pentobarbitone. Intravenous administration of chloroquine.
A randomized controlled study in rats: with an evaluation of diazepam, clonazepam and Ro5-4864 administered: before / during/after chloroquine + the effects of diazepam: high dose / in rats anesthetized with urethane / co-administered with adrenaline.
Ro5-4864: translocating protein agonist (TSPO) Ro5-4864 (4'-chlorodiazepam)
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