- The RRs for each lifestyle risk factor after adjustment are: 1.32 for physical activity, 1.42 for smoking, 2.05 for obesity. No significant association for excessive alcohol consumption.
- Dose-response relationship between lifestyle risk factor score and risk of hospitalization COVID-19, up to x 4.41.
- A low-level inflammatory syndrome associated with risky lifestyles may mediate this observed risk.
- Population attributable fraction for the combination of smoking, physical inactivity and BMI>25 of 51.4%.
- prospective cohort study
- relatively few cases
- the period of interest is short and far removed from the last risk factor assessment (> 10 years); and
- classification bias very likely because the event taken into account is a hospitalisation with a positive SARS-CoV-2 test (the tests being reserved for this period for hospitalised persons with symptoms compatible with COVID-19) and not persons with a diagnosis of severe COVID-19 requiring hospitalisation in the strict sense of the term.
- subgroup analysis appearing to be performed retrospectively (not detailed in the methods).
- pre-proof
- Prospective cohort study based on the UK Biobank cohort.
- Initial collection of data on smoking, alcohol consumption and physical activity levels by questionnaire and measured BMI over the period 2006-2010.
- Collection of cases of COVID-19 hospitalized in England for the period from 16 March to 26 April 2020.
- Weighting for risk factors: smoking (0=never, 1=severe, 2=active), physical activity (0=compliant with recommendations, 1=active but below recommendations, 2=inactive), alcohol consumption (0=abstinent or very occasional consumption, 1=moderate consumption not exceeding recommendations, 2=heavy consumption exceeding recommendations), BMI (0=BMI<25, 1=overweight, 2=obesity). Highest score 0, Lowest score 8.
- Calculation of RR with 95% CI and adjustment for age, sex, then education, ethnicity, diabetes, hypertension and cardiovascular disease.
- Calculation of the population attributable fraction (PAF) based on the prevalence study of the Health Survey for England.
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