-Lack of details on patient's follow-up
-Division of the cohort into several sub-groups, some with a few dozens of patients which induces a lack of power and increases the risk of a wrong conclusion (inflation of the alpha risk not acknowledged)
- In the end, the performed analysis is a per-protocol analysis when an analysis with intent to treat should have been done and all the patients which have not properly followed the bi-therapy should have been included in the same group to increase robustness
- Population not representative: the cohort is young with a majority of women, however, severe cases are in majority older males, which prevents concluding on mortality or ICU transfer.
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