Scientific Watch on COVID-19

- Déterminer si l'obésité est associée à l'intubation ou le décès au cours de l'infection au SARS-CoV-2 - Déterminer si l'obésité est associée à l'inflammation, aux lésions cardiaques ou à la fibrinolyse dans la COVID-19

Test different treatment strategies with hydroxychloroquine alone or in combination with azithromycin in macaques infected with SARS-CoV-2 before or after maximal viral replication.

The goal of this study is to determine the infectivity profile of an individual –that is, the temporal distribution of new infections from that individual—around the time of the appearance of symptoms. An earlier analysis by He et al., based on a study of the time to the appearance of symptoms in 77 confirmed cases, showed that individuals infected with SARS-CoV-2 become contagious approximately 2.5 days before showing symptoms. This article redoes the original analysis from the same data, and in correcting an error in the analysis, the authors demonstrate that the pre-symptomatic contagious period could have been underestimated.

The objective of this study is to determine strategies that permit control of an epidemic by limiting the maximum number of deaths due to the epidemic, as well as the cost associated with the control policy. Specifically, the article incorporates increases in mortality due to saturation of the health care system. Different “actualized” strategies are also considered, such as a control policy unrolled at regular intervals, a constant control policy, or alternation between periods of maximal (complete containment) and minimal control.

The goal of this article is to study the impact of individual considerations on organization of quarantine measures to control an epidemic. The model considered here is that of an SIR-type epidemic; that is, a dynamic epidemic in a large population. The goal of the centralized quarantine strategy is to minimize the total number of people infected and the time spent in quarantine, while the goal of the individuals is not to be infected, and to be in quarantine for as little time as possible. The article compares the results of the centralized strategy and the individual strategy, and thus measures the “price of anarchy,” the number of secondary infections due to the absence of centralized planning.

Accelerated development of the Moderna mRNA-1273 vaccine in Phase I: presentation of preliminary results on its ability to induce an immune response against the SARS-CoV-2 infection and investigation of the first side effects, tolerance during its use in humans and the minimum effective dose.

Bibliographic review of knowledge on the known coronaviruses SARS-CoV-2, SARS-CoV, and MERS-CoV.

To study how the SARS-Cov-2 epidemic started in the north of France.

To determine risk factors associated with mortality in a quantitative cohort study on the general English population from collection of national data.

Estimate the distribution of the number of secondary cases, and in particular their over-dispersion (parameter k of a negative binomial distribution).

The aim of the study is to predict the impact of the reopening of schools (nursery, elementary, middle and high schools) from May 11 on the spread of the virus in Île-de-France. Several scenarios are compared: continued closure, partial reopening, gradual reopening, complete reopening. The article addresses the issue of uncertainty on susceptibility and infectivity depending on the age group and several parameters are tested.

The authors divide the population into several groups: people visiting "fever clinics", hospitalised people (different services in the hospital), health care staff (in different types of services and in "fever clinics"), and the general public, and look for the best allocation of PCR tests to detect the earliest cases of SARS-CoV-2 infection.

To describe the experience of universities in Taiwan during the COVID-19 crisis

To conduct a seroprevalence survey among blood donors as a surveillance tool for the SARS-CoV-2 epidemic.

Décrire la présentation clinique, les complications et les résultats des patients pédiatriques atteints du syndrome inflammatoire multisystémique (MIS-C) et du Covid-19.

Résumer l'épidémiologie et les caractéristiques cliniques de 186 cas de MIS-C signalés à l'étude Overcoming COVID-19 et aux CDC par des cliniciens dans 26 États aux États-Unis.

Répertorier/expliquer l'usage possible des agents anesthésiques inhalés devant la pénurie de médicaments, la possible épargne en sédatifs et curares ainsi que l'effet bronchodilatateur et anti-inflammatoire (absence de bénéfice thérapeutique actuellement prouvé hormis sur l'oxygénation du SDRA).

To present the evolution of a cohort positive for SARS-CoV-2 and treated with hydroxychloroquine and azithromycin