13.03.2020
Thrombocytopenia is associated with severe coronavirus disease 2019 (COVID-19) infections: A meta-analysis
Epidemiology Transversal
Lippi G et al
Clin Chim Acta
Main result
Platelet count: 7 studies out of a total of 9 found that patients with severe forms of COVID-19 have a lower platelet count than patients with moderate forms (mean difference between -3 and -54x10 ° 9 / L ).
2 studies show that patients with a non-severe form of the disease have a lower platelet numeration (mean difference between 27 and 31 x 10 ° 9 / L).
Meta-analysis suggests that the platelet count is statistically lower in patients with severe forms of COVID-19 (P <0.001), the results remain significant even with the exclusion of the study with the largest sample size (Guan et al, 1099 patients).
Thrombocytopenia: 4 studies (out of 9 total studies) report the values for thrombocytopenia. In these, platelet numerations below the lower threshold were associated with severity.
2 studies show that patients with a non-severe form of the disease have a lower platelet numeration (mean difference between 27 and 31 x 10 ° 9 / L).
Meta-analysis suggests that the platelet count is statistically lower in patients with severe forms of COVID-19 (P <0.001), the results remain significant even with the exclusion of the study with the largest sample size (Guan et al, 1099 patients).
Thrombocytopenia: 4 studies (out of 9 total studies) report the values for thrombocytopenia. In these, platelet numerations below the lower threshold were associated with severity.
Takeaways
The reduction in the number of platelets is significantly different between severe and non-severe cases.
Thrombocytopenia is associated with a five-fold increase in the risk of falling into a severe condition.
Thrombocytopenia is associated with a five-fold increase in the risk of falling into a severe condition.
Strength of evidence Moderate
"moderate
1) 9 studies in meta-analysis (including 8 Chinese studies and 1 Singapore study).
A total of 1779 patients / sample varies between 12 and 1099 patients per study
2) 4 studies (out of 9) provide the value of trompocytopenia (total of 1427 patients)
3) 399 patients (22.4%) with severe patology"
Objectives
Determine if the platelet count can be used as a predictor for severity.
Assess whether thrombocytopenia is associated with a severe form of COVID-19
Assess whether thrombocytopenia is associated with a severe form of COVID-19
Method
A meta-analysis of 9 studies (8 Chinese and 1 from Singapore)
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